Publications

Swan, C. T., Edmonds, A. G., Argent, S. P., Mitchell, N. J.; A Modular and Scalable Route to Protected Cyclopropane Amino Acid Building Blocks; Org. Lett.; 2025; 27; 18; 4800-4805

Aljohani, S., Edmonds, A. G., Castelletto, V., Seitsonen, J., Hamley, I. W., Symonds, P., Brentville, V. A., Durrant, L. G., Mitchell, N. J.; In Vivo Evaluation of Pam2Cys-Modified Cancer-Testis Antigens as Potential Self-Adjuvanting Cancer Vaccines; J. Pept. Sci.; 2025; 31; e70022

Smith, F. R., Meehan, D., Griffiths, R. C., Knowles, H., Zhang, P., Williams, H. E. L., Wilson, A. J., Mitchell, N. J.; Peptide Macrocyclisation via Intramolecular Interception of Visible-Light-Mediated Desulfurisation; Chem. Sci.; 2024; 15; 9612-9619

Lee, J. C., Cuthbertson, J. D., Mitchell, N. J.; Chemoselective Late-Stage Functionalization of Peptides via Photocatalytic C2-Alkylation of Tryptophan; Org. Lett.; 2023; 23; 5459-5464

Bombana, A., Shanmugam, M., Collison, D., Kibler, A. J., Newton, G. N., Jager, C. M., Croft, A. K., Morra, S., Mitchell, N. J.; Application of a Synthetic Ferredoxin-Inspired [4Fe4S]-Peptide Maquette as the Redox Partner for an [FeFe]-Hydrogenase; ChemBioChem; 2023; 24; e202300250

Amin, S. S., Jones, K. D., Kibler, A. J., Damian, H. A., Cameron, J. M., Butler, K. S., Argent, S. P., Winslow, M., Robinson, D., Mitchell, N. J., Lam, H. W., Newton, G. N.; Diphosphoryl‐functionalized Polyoxometalates: Structurally and Electronically Tunable Hybrid Molecular Materials; Angew. Chem. Int. Ed.; 2023; 62; e202302446

Griffiths, R. C., Smith, F. R., Li, D., Wyatt, J., Rogers, D. M., Long, J. E., Cusin, L. M. L., Tighe, P. J., Layfield, R., Hirst, J. D., Muller, M. M., Mitchell, N. J.; Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C-C Bond Formation; Chem. Eur. J.; 2023; 29; e202202503

Griffiths, R. C., Smith, F. R., Long, J. E., Scott, D., Williams, H. E. L., Oldham, N. J., Layfield, R., Mitchell, N. J.; Site-Selective Installation of N-Epsilon-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C-C Bond Formation; Angew. Chem. Int. Ed.; 2022; 61; e202110223

Karyal, C., Palazi P., Hughes, J., Griffiths, R. C., Persaud, R. P., Tighe, P J., Mitchell, N. J., Griffin, R.; Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against Clostridioides difficile; Vaccines; 2021, 9(12); 1453

Griffiths, R. C. and Mitchell, N. J.; The Chemical Synthesis of Site-Specifically Modified Proteins via Diselenide-Selenoester Ligation; Peptide Conjugation - Methods and Protocols; Springer Protocols; 2021; 2355; 231-251

Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H. E. L., Layfield, R., Mitchell, N. J.; Site-Selective Modification of Peptides and Proteins via Interception of Free Radical-Mediated Dechalcogenation; Angew. Chem. Int. Ed.; 2020; 59; 23659-23667

Sayers, J., Karpati, P. M. T., Mitchell, N. J., Goldys, A. M., Kwong, S. M., Firth, N., Chan, B. and Payne, R. J.; Construction of Challenging Proline-Proline Junctions via Diselenide-Selenoester Ligation Chemistry; J. Am. Chem. Soc. 2018; 140; 13327-13334

Bofinger, R., Zaw-Thin, M., Mitchell, N. J., Patrick, P. S., Stowe, C., Gomez-Ramirez, A., Hailes, H. C., Kalber, T. L. and Tabor, A. B.; Development of lipopolyplexes for gene delivery: a comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes; J. Pept. Sci. 2018; 24; e3131

Mitchell, N. J., Sayers, J., Clayton, D., Kulkarni, S. S., Goldys, A. M., Ripoll-Rozada, J., Pereira, P. J. B., Chan, B., Radom, L. and Payne, R. J.; Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry; Chem 2017; 2; 703-715

Weitsman, G., Mitchell, N. J., Evans, R., Cheung, A., Kalber, T. L., Bofinger, R., Fruhwirth, G. O., Keppler, M., Wright, Z. V. F., Barber, P. R., Gordon, P., Koning, T. D., Wulaningsih, W., Sander, K., Vojnovic, B., Ameer-Beg, S., Lythgoe, M., Arnold, J. N., Årstad, E., Festy, F., Hailes, H. C., Tabor, A. B., Ng, T.; Detecting Intratumoral Heterogeneity of EGFR Activity by Liposome-Based In Vivo Transfection of a Fluorescent Biosensor; Oncogene 2017; 36; 3618-3628

Mitchell, N. J., Kulkarni, S. S., Malins, L. R., Wang, S. and Payne, R. J.; One-Pot Ligation-Oxidative Deselenization at Selenocystine and Selenocysteine; Chem. Eur. J. 2017; 23; 946-952

Isahak, N., Gody, G., Malins, L. R., Mitchell, N. J., Payne, R. J. and Perrier, S.; Single Addition of an Allyl Amine Monomer Enables Access to End-Functionalized RAFT Polymers for Native Chemical Ligation; Chem. Commun. 2016; 52; 12952-12955

Rogers, S., Fey, D., McCloy, R. A., Parker, B. L., Mitchell, N. J., Payne, R. J., Daly, R. J., James, D. E., Caldon, C. E., Watkins, D. N., Croucher, D. R., Burgess, A.; PP1 Initiates the Dephosphorylation of MASTL, Triggering Mitotic Exit and Bistability in Human Cells; J. Cell Sci. 2016; 129(7); 1340-1354

Mitchell, N. J., Malins, L. R., Liu, X., Thompson, R. E., Chan, B., Radom, L. and Payne, R. J.; Rapid Additive-Free Selenocystine−Selenoester Peptide Ligation; J. Am. Chem. Soc. 2015; 137; 14011-14014

Malins, L. R., Mitchell, N. J., McGowan, S. and Payne, R. J.; Oxidative Deselenization of Selenocysteine-Applications for Programmed Ligation at Serine; Angew. Chem. Int. Ed. 2015; 54; 12716-12721

Malins, L. R., Mitchell, N. J. and Payne, R. J.; Peptide Ligation Chemistry at Selenol Amino Acids; J. Pept. Sci. 2014; 20; 64-77

Mitchell, N., Kalber, T. L., Cooper, M. S., Sunassee, K., Chalker, S. L., Shaw, K. P., Ordidge, K. L., Bader, A., Janes, S. M., Blower, P. L., Lythgoe, M. F., Hailes, H. C., Tabor, A. B.; Incorporation of Paramagnetic, Fluorescent and PET/SPECT Contrast Agents into Liposomes for Multimodal Imaging; Biomaterials 2013; 34; 1179- 1192

Buchsbaum, S., Mitchell, N., Martin, H., Wiggin, M., Marziali, A., Coveney, P. V., Siwy, Z., Howorka, S.; Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space; Nano Lett. 2013; 13; 3890-3896

Leitner, M., Mitchell, N., Kastner, M., Schlapak, R., Gruber, H. J., Hinterdorfer, P., Howorka, S., Ebner, A.; Single-Molecule AFM Characterization of Individual Chemically Tagged DNA Tetrahedra; ACS Nano 2011; 5; 7048-7054

Mitchell, N., Ebner, A., Hinterdorfer, P., Tampe, R. and Howorka, S.; Chemical Tags Mediate the Orthogonal Self-Assembly of DNA Duplexes into Supramolecular Structures; Small 2010; 6; 1732- 1735

Mitchell, N., Schlapak, R., Kastner, M., Armitage, D., Chrzanowski, W., Riener, J., Hinterdorfer, P., Ebner, A., Howorka S; A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry; Angew. Chem. Int. Ed. 2009; 48; 525-527

Borsenberger, V., Mitchell, N. and Howorka, S.; Chemically Labeled Nucleotides and Oligonucleotides Encode DNA for Sensing with Nanopores; J. Am. Chem. Soc. 2009; 131; 7530-7531

Mitchell, N. and Howorka, S.; Chemical Tags Facilitate the Sensing of Individual DNA Strands with Nanopores; Angew. Chem. Int. Ed. 2008; 47; 5565-5568

Martin, H., Kinns, H., Mitchell, N., Astier, Y., Madathil, R. and Howorka, S.; Nanoscale Protein Pores Modified with PAMAM Dendrimers; J. Am. Chem. Soc. 2007; 129; 9640-9649

Patents

Mitchell, N. J., Malins, L. R. and Payne, R. J.; New Synthetic Methods; WO2016138563; filed 03/2015

Mitchell, N., Borsenberger, V. and Howorka, S.; Nucleic Acid Detection Method; WO2009007743; filed 01/2009