themitchellgroup

Smith, F. R., Griffiths, R. C., Meehan, D., Knowles, H., Zhang, P., Williams, H. E. L., Wilson, A. J., Mitchell, N. J.; Peptide Macrocyclization via Intramolecular Interception of Visible-Light-Mediated Desulfurization; ChemRxiv.; 2023; DOI: 10.26434/chemrxiv-2023-865v6​

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Lee, J. C., Cuthbertson, J. D., Mitchell, N. J.; Chemoselective Late-Stage Functionalization of Peptides via Photocatalytic C2-Alkylation of Tryptophan; Org. Lett.; 2023; 23; 5459-5464

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Bombana, A., Shanmugam, M., Collison, D., Kibler, A. J., Newton, G. N., Jager, C. M., Croft, A. K., Morra, S., Mitchell, N. J.; Application of a Synthetic Ferredoxin-Inspired [4Fe4S]-Peptide Maquette as the Redox Partner for a [FeFe]-Hydrogenase; ChemBioChem; 2023; 24; e202300250

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Amin, S. S., Jones, K. D., Kibler, A. J., Damian, H. A., Cameron, J. M., Butler, K. S., Argent, S. P., Winslow, M., Robinson, D., Mitchell, N. J., Lam, H. W., Newton, G. N.; Diphosphoryl‐functionalized Polyoxometalates: Structurally and Electronically Tunable Hybrid Molecular Materials; Angew. Chem. Int. Ed.; 2023; 62; e202302446

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Griffiths, R. C., Smith, F. R., Li, D., Wyatt, J., Rogers, D. M., Long, J. E., Cusin, L. M. L., Tighe, P. J., Layfield, R., Hirst, J. D., Muller, M. M., Mitchell, N. J.; Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C-C Bond Formation; Chem. Eur. J.; 2023; 29; e202202503

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Griffiths, R. C., Smith, F. R., Long, J. E., Scott, D., Williams, H. E. L., Oldham, N. J., Layfield, R., Mitchell, N. J.; Site-Selective Installation of N-Epsilon-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C-C Bond Formation; Angew. Chem. Int. Ed.; 2022; 61; e202110223

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Karyal, C., Palazi P., Hughes, J., Griffiths, R. C., Persaud, R. P., Tighe, P J., Mitchell, N. J., Griffin, R.; Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against Clostridioides difficile; Vaccines; 2021, 9(12); 1453

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Griffiths, R. C. and Mitchell, N. J.; The Chemical Synthesis of Site-Specifically Modified Proteins via Diselenide-Selenoester Ligation; Peptide Conjugation - Methods and Protocols; Springer Protocols;  2021; 2355; 231-251

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Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H. E. L., Layfield, R., Mitchell, N. J.; Site-Selective Modification of Peptides and Proteins via Interception of Free Radical-Mediated Dechalcogenation; Angew. Chem. Int. Ed.; 2020; 59; 23659-23667

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Sayers, J., Karpati, P. M. T., Mitchell, N. J., Goldys, A. M., Kwong, S. M., Firth, N., Chan, B. and Payne, R. J.; Construction of Challenging Proline-Proline Junctions via Diselenide-Selenoester Ligation Chemistry; J. Am. Chem. Soc. 2018; 140; 13327-13334

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Bofinger, R., Zaw-Thin, M., Mitchell, N. J., Patrick, P. S., Stowe, C., Gomez-Ramirez, A., Hailes, H. C., Kalber, T. L. and Tabor, A. B.; Development of lipopolyplexes for gene delivery: a comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes; J. Pept. Sci. 2018; 24; e3131

 

 

Mitchell, N. J., Sayers, J., Clayton, D., Kulkarni, S. S., Goldys, A. M., Ripoll-Rozada, J., Pereira, P. J. B., Chan, B., Radom, L. and Payne, R. J.; Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry; Chem 2017; 2; 703-715 

 

 

Weitsman, G., Mitchell, N. J., Evans, R., Cheung, A., Kalber, T. L., Bofinger, R., Fruhwirth, G. O., Keppler, M., Wright, Z. V. F., Barber, P. R., Gordon, P., Koning, T. D., Wulaningsih, W., Sander, K., Vojnovic, B., Ameer-Beg, S., Lythgoe, M., Arnold, J. N., Årstad, E., Festy, F., Hailes, H. C., Tabor, A. B., Ng, T.; Detecting Intratumoral Heterogeneity of EGFR Activity by Liposome-Based In Vivo Transfection of a Fluorescent Biosensor; Oncogene 2017; 36; 3618-3628

 

 

Mitchell, N. J., Kulkarni, S. S., Malins, L. R., Wang, S. and Payne, R. J.; One-Pot Ligation-Oxidative Deselenization at Selenocystine and Selenocysteine; Chem. Eur. J. 2017; 23; 946-952 

 

 

Isahak, N., Gody, G., Malins, L. R., Mitchell, N. J., Payne, R. J. and Perrier, S.; Single Addition of an Allyl Amine Monomer Enables Access to End-Functionalized RAFT Polymers for Native Chemical Ligation; Chem. Commun. 2016; 52; 12952-12955 

 

 

Rogers, S., Fey, D., McCloy, R. A., Parker, B. L., Mitchell, N. J., Payne, R. J., Daly, R. J., James, D. E., Caldon, C. E., Watkins, D. N., Croucher, D. R., Burgess, A.; PP1 Initiates the Dephosphorylation of MASTL, Triggering Mitotic Exit and Bistability in Human Cells; J. Cell Sci. 2016; 129(7); 1340-1354

 

 

Mitchell, N. J., Malins, L. R., Liu, X., Thompson, R. E., Chan, B., Radom, L. and Payne, R. J.; Rapid Additive-Free Selenocystine−Selenoester Peptide Ligation; J. Am. Chem. Soc. 2015; 137; 14011-14014

 

 

Malins, L. R., Mitchell, N. J., McGowan, S. and Payne, R. J.; Oxidative Deselenization of Selenocysteine-Applications for Programmed Ligation at Serine; Angew. Chem. Int. Ed. 2015; 54; 12716-12721

 

 

Malins, L. R., Mitchell, N. J. and Payne, R. J.; Peptide Ligation Chemistry at Selenol Amino Acids; J. Pept. Sci. 2014; 20; 64-77

 

 

Mitchell, N., Kalber, T. L., Cooper, M. S., Sunassee, K., Chalker, S. L., Shaw, K. P., Ordidge, K. L., Bader, A., Janes, S. M., Blower, P. L., Lythgoe, M. F., Hailes, H. C., Tabor, A. B.; Incorporation of Paramagnetic, Fluorescent and PET/SPECT Contrast Agents into Liposomes for Multimodal Imaging; Biomaterials 2013; 34; 1179- 1192

 

 

Buchsbaum, S., Mitchell, N., Martin, H., Wiggin, M., Marziali, A., Coveney, P. V., Siwy, Z., Howorka, S.; Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space; Nano Lett. 2013; 13; 3890-3896

 

 

Leitner, M., Mitchell, N., Kastner, M., Schlapak, R., Gruber, H. J., Hinterdorfer, P., Howorka, S., Ebner, A.; Single-Molecule AFM Characterization of Individual Chemically Tagged DNA Tetrahedra; ACS Nano 2011; 5; 7048-7054

 

 

Mitchell, N., Ebner, A., Hinterdorfer, P., Tampe, R. and Howorka, S.; Chemical Tags Mediate the Orthogonal Self-Assembly of DNA Duplexes into Supramolecular Structures; Small 2010; 6; 1732- 1735

 

 

Mitchell, N., Schlapak, R., Kastner, M., Armitage, D., Chrzanowski, W., Riener, J., Hinterdorfer, P., Ebner, A., Howorka S; A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry; Angew. Chem. Int. Ed. 2009; 48; 525-527

 

 

Borsenberger, V., Mitchell, N. and Howorka, S.; Chemically Labeled Nucleotides and Oligonucleotides Encode DNA for Sensing with Nanopores; J. Am. Chem. Soc. 2009; 131; 7530-7531

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Mitchell, N. and Howorka, S.; Chemical Tags Facilitate the Sensing of Individual DNA Strands with Nanopores; Angew. Chem. Int. Ed. 2008; 47; 5565-5568

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Martin, H., Kinns, H., Mitchell, N., Astier, Y., Madathil, R. and Howorka, S.; Nanoscale Protein Pores Modified with PAMAM Dendrimers; J. Am. Chem. Soc. 2007; 129; 9640-9649