peptide chemistry | synthetic chemistry | chemical biology
Based in the School of Chemistry, University of Nottingham, the group's research activities focus on the chemical synthesis and investigation of native and engineered peptides and proteins. Current projects include the investigation of site-selective methods to modify peptides and proteins, the formulation of antigenic lipoproteins to treat cancer, and the development of peptide-based catalysts inspired by metalloenzymes.
Griffiths, R. C., Smith, F. R., Long, J. E., Scott, D., Williams, H. E. L., Oldham, N. J., Layfield, R., Mitchell, N. J.; Site-Selective Installation of N-Epsilon-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C-C Bond Formation; Angew. Chem. Int. Ed.; 2022; 61; e202110223
Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H., Layfield, R., Mitchell, N. J.; Site-Selective Modification of Peptides and Proteins via Interception of Free Radical-Mediated Dechalcogenation; Angew. Chem. Int. Ed.; 2020; 59; 23659-23667
Sayers, J., Karpati, P. M. T., Mitchell, N. J., Goldys, A. M., Kwong, S. M., Firth, N., Chan, B. and Payne, R. J.; Construction of Challenging Proline-Proline Junctions via Diselenide-Selenoester Ligation Chemistry; J. Am. Chem. Soc. 2018; 140; 13327-13334
Mitchell, N. J., Sayers, J., Clayton, D., Kulkarni, S. S., Goldys, A. M., Ripoll-Rozada, J., Pereira, P. J. B., Chan, B., Radom, L. and Payne, R. J.; Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry; Chem 2017; 2; 703-715
Mitchell, N. J., Malins, L. R., Liu, X., Thompson, R. E., Chan, B., Radom, L. and Payne, R. J.; Rapid Additive-Free Selenocystine−Selenoester Peptide Ligation; J. Am. Chem. Soc. 2015; 137; 14011-14014
Malins, L. R., Mitchell, N. J., McGowan, S. and Payne, R. J.; Oxidative Deselenization of Selenocysteine-Applications for Programmed Ligation at Serine; Angew. Chem. Int. Ed. 2015; 54; 12716-12721
Prospective PhD students can apply through one of the doctoral training centres established here at Nottingham (click on research council links below). Contact me prior to application to discuss potential projects. PhD places in the group will also be posted on this site and findaphd.com when available.
Postdoc positions will be advertised here and on jobs.ac.uk when available. I would be happy to support fellowship applications (Marie Curie, Leverhulme Trust etc.) from competitive candidates.