themitchellgroup
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Mitchell Group
peptide chemistry | synthetic chemistry | chemical biology
Based in the School of Chemistry, University of Nottingham, the group's research activities focus on the chemical synthesis and investigation of native and engineered peptides and proteins. Current projects include the investigation of site-selective methods to modify peptides and proteins, the formulation of antigenic lipoproteins to treat cancer, and the development of peptide-based catalysts inspired by metalloenzymes.
Selected Publications
Griffiths, R. C., Smith, F. R., Long, J. E., Scott, D., Williams, H. E. L., Oldham, N. J., Layfield, R., Mitchell, N. J.; Site-Selective Installation of N-Epsilon-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C-C Bond Formation; Angew. Chem. Int. Ed.; 2022; 61; e202110223
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Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H., Layfield, R., Mitchell, N. J.; Site-Selective Modification of Peptides and Proteins via Interception of Free Radical-Mediated Dechalcogenation; Angew. Chem. Int. Ed.; 2020; 59; 23659-23667
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Sayers, J., Karpati, P. M. T., Mitchell, N. J., Goldys, A. M., Kwong, S. M., Firth, N., Chan, B. and Payne, R. J.; Construction of Challenging Proline-Proline Junctions via Diselenide-Selenoester Ligation Chemistry; J. Am. Chem. Soc. 2018; 140; 13327-13334
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Mitchell, N. J., Sayers, J., Clayton, D., Kulkarni, S. S., Goldys, A. M., Ripoll-Rozada, J., Pereira, P. J. B., Chan, B., Radom, L. and Payne, R. J.; Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry; Chem 2017; 2; 703-715
Mitchell, N. J., Malins, L. R., Liu, X., Thompson, R. E., Chan, B., Radom, L. and Payne, R. J.; Rapid Additive-Free Selenocystine−Selenoester Peptide Ligation; J. Am. Chem. Soc. 2015; 137; 14011-14014
Malins, L. R., Mitchell, N. J., McGowan, S. and Payne, R. J.; Oxidative Deselenization of Selenocysteine-Applications for Programmed Ligation at Serine; Angew. Chem. Int. Ed. 2015; 54; 12716-12721
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Opportunities
Prospective PhD students can apply through one of the doctoral training centres established here at Nottingham (click on research council links below). Contact me prior to application to discuss potential projects. PhD places in the group will also be posted on this site and findaphd.com when available.
Postdoc positions will be advertised here and on jobs.ac.uk when available. I would be happy to support fellowship applications (Marie Curie, Leverhulme Trust etc.) from competitive candidates.
Contact us
School of Chemistry
University of Nottingham
University Park
Nottingham
NG7 2RD
UK
nicholas.mitchell@nottingham.ac.uk
+44 (0)115 748 7065