chem 2
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Mitchell group

peptide chemistry | synthetic chemistry | chemical biology

Based in the School of Chemistry, University of Nottingham, the group's research activities focus on the chemical synthesis and investigation of native and engineered peptides and proteins. Current projects include the investigation of site-selective methods to modify peptides and proteins, the formulation of antigenic lipoproteins to treat cancer, and the development of peptide-based catalysts inspired by metalloenzymes.

Selected Publications

Griffiths, R. C., Smith, F. R., Long, J. E., Scott, D., Williams, H. E. L., Oldham, N. J., Layfield, R., Mitchell, N. J.; Site-Selective Installation of N-Epsilon-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C-C Bond FormationAngew. Chem. Int. Ed.2022; DOI: 10.1002/anie.202110223

Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H., Layfield, R., Mitchell, N. J.; Site-Selective Modification of Peptides and Proteins via Interception of Free Radical-Mediated Dechalcogenation; Angew. Chem. Int. Ed.; 2020; 59; 23659-23667

Sayers, J., Karpati, P. M. T., Mitchell, N. J., Goldys, A. M., Kwong, S. M., Firth, N., Chan, B. and Payne, R. J.; Construction of Challenging Proline-Proline Junctions via Diselenide-Selenoester Ligation Chemistry; J. Am. Chem. Soc. 2018140; 13327-13334

Mitchell, N. J., Sayers, J., Clayton, D., Kulkarni, S. S., Goldys, A. M., Ripoll-Rozada, J., Pereira, P. J. B., Chan, B., Radom, L. and Payne, R. J.; Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry; Chem 2017; 2; 703-715 



Mitchell, N. J., Malins, L. R., Liu, X., Thompson, R. E., Chan, B., Radom, L. and Payne, R. J.; Rapid Additive-Free Selenocystine−Selenoester Peptide Ligation; J. Am. Chem. Soc. 2015; 137; 14011-14014



Malins, L. R., Mitchell, N. J., McGowan, S. and Payne, R. J.; Oxidative Deselenization of Selenocysteine-Applications for Programmed Ligation at Serine; Angew. Chem. Int. Ed. 2015; 54; 12716-12721




Prospective PhD students can apply through one of the doctoral training centres established here at Nottingham (click on research council links below). Contact me prior to application to discuss potential projects. PhD places in the group will also be posted on this site and when available.

Postdoc positions will be advertised here and on when available. I would be happy to support fellowship applications (Marie Curie, Leverhulme Trust etc.) from competitive candidates.



Contact us

School of Chemistry

University of Nottingham

University Park




+44 (0)115 748 7065