Nicholas J. Mitchell

peptide chemistry | synthetic chemistry | chemical biology

Show More

Based in the School of Chemistry, University of Nottingham, the group's research activities focus on the chemical synthesis and investigation of native and engineered peptides and proteins. Current projects include the investigation of site-selective methods to install post-translational modifications, the formulation of antigenic lipoproteins to combat bacterial infection and the development of direct fluorination techniques.

Selected Publications

Sayers, J., Karpati, P. M. T., Mitchell, N. J., Goldys, A. M., Kwong, S. M., Firth, N., Chan, B. and Payne, R. J.; Construction of Challenging Proline-Proline Junctions via Diselenide-Selenoester Ligation Chemistry; J. Am. Chem. Soc. 2018140; 13327-13334

Mitchell, N. J., Sayers, J., Clayton, D., Kulkarni, S. S., Goldys, A. M., Ripoll-Rozada, J., Pereira, P. J. B., Chan, B., Radom, L. and Payne, R. J.; Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry; Chem 2017; 2; 703-715 



Mitchell, N. J., Malins, L. R., Liu, X., Thompson, R. E., Chan, B., Radom, L. and Payne, R. J.; Rapid Additive-Free Selenocystine−Selenoester Peptide Ligation; J. Am. Chem. Soc. 2015; 137; 14011-14014



Malins, L. R., Mitchell, N. J., McGowan, S. and Payne, R. J.; Oxidative Deselenization of Selenocysteine-Applications for Programmed Ligation at Serine; Angew. Chem. Int. Ed. 2015; 54; 12716-12721



Mitchell, N., Schlapak, R., Kastner, M., Armitage, D., Chrzanowski, W., Riener, J., Hinterdorfer, P., Ebner, A., Howorka S; A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry; Angew. Chem. Int. Ed. 2009; 48; 525-527



Borsenberger, V., Mitchell, N. and Howorka, S.; Chemically Labeled Nucleotides and Oligonucleotides Encode DNA for Sensing with Nanopores; J. Am. Chem. Soc. 2009; 131; 7530-7531



Mitchell, N. and Howorka, S.; Chemical Tags Facilitate the Sensing of Individual DNA Strands with Nanopores; Angew. Chem. Int. Ed. 2008; 47; 5565-5568



Martin, H., Kinns, H., Mitchell, N., Astier, Y., Madathil, R. and Howorka, S.; Nanoscale Protein Pores Modified with PAMAM Dendrimers; J. Am. Chem. Soc. 2007; 129; 9640-9649


Prospective PhD students can apply through one of the doctoral training centres established here at Nottingham (click on research council links below). Contact me prior to application to discuss potential projects. PhD places in the group will also be posted on this site and when available.

Postdoc positions will be advertised here and on when available. I would be happy to support fellowship applications (Marie Curie, Leverhulme Trust etc.) from competitive candidates.



Contact us

School of Chemistry

University of Nottingham

University Park




+44 (0)115 748 7065

This site was designed with the
website builder. Create your website today.
Start Now