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Mitchell Group

peptide chemistry | synthetic chemistry | chemical biology

Based in the School of Chemistry, University of Nottingham, the group's research activities focus on the development of new bioconjugation methodology. Current projects include the exploration of photocatalytic, biocatalytic, and electrochemical methods for the site-selective modification of peptides and proteins.

Selected Publications

Smith, F. R., Meehan, D., Griffiths, R. C., Knowles, H., Zhang, P., Williams, H. E. L., Wilson, A. J., Mitchell, N. J.; Peptide Macrocyclisation via Intramolecular Interception of Visible-Light-Mediated Desulfurisation; Chem. Sci.; 2024; 15; 9612-9619

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Lee, J. C., Cuthbertson, J. D., Mitchell, N. J.; Chemoselective Late-Stage Functionalization of Peptides via Photocatalytic C2-Alkylation of Tryptophan; Org. Lett.; 2023; 23; 5459-5464

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Bombana, A., Shanmugam, M., Collison, D., Kibler, A. J., Newton, G. N., Jager, C. M., Croft, A. K., Morra, S., Mitchell, N. J.; Application of a Synthetic Ferredoxin-Inspired [4Fe4S]-Peptide Maquette as the Redox Partner for an [FeFe]-Hydrogenase; ChemBioChem; 2023; 24; e202300250

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Griffiths, R. C., Smith, F. R., Li, D., Wyatt, J., Rogers, D. M., Long, J. E., Cusin, L. M. L., Tighe, P. J., Layfield, R., Hirst, J. D., Muller, M. M., Mitchell, N. J.; Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C-C Bond Formation; Chem. Eur. J.; 2023; 29; e202202503

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Griffiths, R. C., Smith, F. R., Long, J. E., Scott, D., Williams, H. E. L., Oldham, N. J., Layfield, R., Mitchell, N. J.; Site-Selective Installation of N-Epsilon-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C-C Bond Formation; Angew. Chem. Int. Ed.; 2022; 61; e202110223

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Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H. E. L., Layfield, R., Mitchell, N. J.; Site-Selective Modification of Peptides and Proteins via Interception of Free Radical-Mediated Dechalcogenation; Angew. Chem. Int. Ed.; 2020; 59; 23659-23667

Opportunities

Prospective PhD students can apply through one of the doctoral training centres established here at Nottingham (click on research council links below). Contact me prior to application to discuss potential projects. PhD places in the group will also be posted on this site and findaphd.com when available.

Postdoc positions will be advertised here and on jobs.ac.uk when available. I would be happy to support fellowship applications (Marie Curie, Leverhulme Trust etc.) from competitive candidates.

 

 

Contact us

School of Chemistry

University of Nottingham

University Park

Nottingham

NG7 2RD

UK

 

nicholas.mitchell@nottingham.ac.uk

+44 (0)115 748 7065

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